This an US English Course of publishing press, two books total.
It needs a little slow speech speed and proper pauses.
Need male's voice.
Please send me demo for below:
Unit 1 Medicinal Chemistry
Task 1 Background Information
Words & Expressions
[url removed, login to view] ['sɪnθəsɪs]
[url removed, login to view] ['fɑːrməsi]
[url removed, login to view] [ˈmɒlɪkju:l]
4. metabolize [mə'tæbəlaɪz]
Text A Beta-lactam Antibiotics
Antibiotics are drugs that kill or stop the growth of bacteria. Beta-lactams are the most widely produced and used antibacterial drugs in the world. All of the drugs in this group contain a beta-lactam ring in their structure. A beta-lactam ring is a four-membered lactam. Penicillin derivatives, cephalosporins, monobactams and carbapenems all belong to this popular class of drugs.
Mode of Action
Beta-lactams exert their bacteriocidal effects in the following ways:
*Bind to penicillin-binding proteins (PBPs)
β-lactams bind to PBPs because they are similar in chemical structure.
* Inhibit synthesis of peptidoglycan
Peptidoglycan is the major component of bacterial cell walls. Bacterial cell wall synthesis is essential to growth, cell division (thus reproduction) and maintaining the cellular structure in bacteria.
* Excite the release of autolysin
An autolysin is an enzyme that hydrolyzes the components of a biological cell. Autolysins exist in all bacteria containing peptidoglycan.
*Lyse cells and then kill bacterial cells.
Autolysins are naturally produced by peptidoglycan containing bacteria, but excessive amounts will cause the cell to burst due to osmotic pressure.
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